Symbol
Name
ID

Zap70
zeta-chain (TCR) associated protein kinase
MGI:99613

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Decreased lymphocyte proliferation in response to mitogen

Panhypogammaglobulinemia

Autoimmune hemolytic anemia

Eosinophilia

Abnormal B cell count

Decreased proportion of CD8-positive T cells

Absence of CD8-positive T cells

Lymphocytosis

Impaired lymphocyte transformation with phytohemagglutinin

Autoimmune thrombocytopenia

Stomatitis

Recurrent upper and lower respiratory tract infections

Abnormal lymph node morphology

Lymphadenitis

Lymphadenopathy

Splenomegaly

Hepatosplenomegaly

Colitis

Recurrent infection of the gastrointestinal tract

Eczematoid dermatitis

Recurrent bacterial skin infections

Chronic mucocutaneous candidiasis

Chronic oral candidiasis

Skin rash

Pneumonia

Pneumocystis carinii pneumonia

Recurrent opportunistic infections

Recurrent bacterial infections

Recurrent mycobacterial infections

Recurrent candida infections

Recurrent respiratory infections

Recurrent viral infections

Disease(s) Associated with ZAP70

immunodeficiency 48

Mouse Phenotypes

immune system phenotype

decreased T cell proliferation

abnormal thymus cell ratio

thymus hypoplasia

abnormal thymocyte activation

abnormal class switch recombination

abnormal T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal T cell selection

abnormal T cell clonal deletion

abnormal positive T cell selection

abnormal double-positive T cell morphology

increased double-positive T cell number

arrested T cell differentiation

increased B cell number

abnormal T cell subpopulation ratio

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

absent CD4-positive, alpha-beta T cells

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

increased memory T cell number

abnormal regulatory T cell number

decreased regulatory T cell number

decreased T cell number

absent T cells

increased activated T cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal splenic cell ratio

increased IgE level

increased IgG1 level

increased IgG2b level

decreased IgG level

increased immunoglobulin level

abnormal T cell physiology

abnormal T cell activation

abnormal regulatory T cell physiology

abnormal lymph node cell ratio

small lymph nodes

abnormal humoral immune response

impaired humoral immune response

increased interleukin-17 secretion

decreased interleukin-2 secretion

decreased susceptibility to induced arthritis

increased susceptibility to induced arthritis

increased autoantibody level

rheumatoid arthritis

chronic joint inflammation

arthritis

lung inflammation

Availability

Mouse Genotype

Zap70^m1Btlr/Zap70^m1Btlr

Zap70^m1Saka/Zap70^m1Saka

Zap70^m2Btlr/Zap70^m2Btlr

Zap70^m3Btlr/Zap70^m3Btlr

Zap70^m4Btlr/Zap70^m4Btlr

Zap70^m5Btlr/Zap70^m5Btlr

Zap70^m6Btlr/Zap70^m6Btlr

Zap70^m6Hefl/Zap70^m6Hefl

Zap70^m7Btlr/Zap70^m7Btlr

Zap70^m8Btlr/Zap70^m8Btlr

Zap70^mrtle/Zap70^mrtle

Zap70^mur/Zap70^mur

Zap70^st/Zap70^st

Zap70^tm1.1Mmal/Zap70^tm1.1Mmal

Zap70^tm1Dlo/Zap70^tm1Dlo

Zap70^tm1Weis/Zap70^tm1Weis

Zap70^tm2.1Mmal/Zap70^tm2.1Mmal

Zap70^tm2.1Weis/Zap70^tm2.1Weis

Zap70^m1Saka/Zap70^tm1Dlo

Zap70^m1Saka/Zap70^tm2.1Weis

Zap70^m6Hefl/Zap70^tm1Weis

Zap70^mrtle/Zap70^rps

Zap70^st/Zap70^tm1Dlo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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